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Antibody germline characterization of cross-neutralizing human IgGs against 4 serotypes of dengue virus.

Authors :
Pitaksajjakul, Pannamthip
Benjathummarak, Surachet
Pipattanaboon, Chonlatip
Wongwit, Waranya
Okabayashi, Tamaki
Kuhara, Motoki
Misaki, Ryo
Fujiyama, Kazuhito
Ramasoota, Pongrama
Source :
Biochemical & Biophysical Research Communications. Apr2014, Vol. 446 Issue 2, p475-480. 6p.
Publication Year :
2014

Abstract

Highlights: [•] VH and VL were isolated from cross-neutralizing 19 HuMAbs specific to dengue virus. [•] VH and VL were analysed with germline sequences using IMGT database. [•] 10 VH and 10 VL germlines were used by our 19 HuMAbs. [•] VH and VL of 3 HuMAbs were used to produce human IgG. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0006291X
Volume :
446
Issue :
2
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
95460343
Full Text :
https://doi.org/10.1016/j.bbrc.2014.02.131