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Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study
- Source :
-
Vaccine . May2003, Vol. 21 Issue 17/18, p2142. 12p. - Publication Year :
- 2003
-
Abstract
- We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (<F>N=2215</F>) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): −0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: −0.17, 0.53), and −0.05 for type B virus (95% CL: −1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study. [Copyright &y& Elsevier]
- Subjects :
- *INFLUENZA viruses
*OBSTRUCTIVE lung diseases
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 21
- Issue :
- 17/18
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 9544484
- Full Text :
- https://doi.org/10.1016/S0264-410X(02)00748-X