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Left Ventricular Systolic Function Following Alcohol Septal Ablation for Symptomatic Hypertrophic Cardiomyopathy.

Authors :
Moss, Travis J.
Krantz, Mori J.
Zipse, Matthew M.
Quaife, Robert A.
Sauer, William H.
Messenger, John C.
Groves, Bertron M.
Salcedo, Ernesto E.
Schuller, Joseph L.
Source :
American Journal of Cardiology. 2014, Vol. 113 Issue 8, p1401-1404. 4p.
Publication Year :
2014

Abstract

Because alcohol septal ablation (ASA) for the treatment of symptomatic hypertrophic cardiomyopathy (HC) with left ventricular (LV) outflow tract (LVOT) obstruction results in a myocardial infarct of up to 10% of ventricular mass, LV systolic function could decline over time. We evaluated LV function during longitudinal follow-up in a cohort of patients who underwent ASA. We studied 145 consecutive patients with HC that underwent 167 ASA procedures from 2002 to 2011. Echocardiographic follow-up was available in 139 patients (96%). Echocardiographic indexes included LV ejection fraction (LVEF), mitral regurgitation severity, systolic anterior motion of the anterior mitral leaflet, and resting and provoked LVOT gradients. All patients had a baseline LVEF of >55%. LVEF was preserved in 97.1% of patients over a mean follow-up time of 3.1 ± 2.3 years (maximum 9.7). Mild LV systolic dysfunction was observed (LVEF range 44% to 54%) in only 4 patients. Mitral regurgitation severity improved in 67% (n[112 of 138 with complete data). Resting LVOT gradient declined from a mean of 75 to 19 mm Hg (p <0.001), and provoked gradient declined from a mean of 101 to 33 mm Hg (p <0.001). New York Heart Association class improved from a mean of 2.9 ± 0.4 to 1.3 ± 0.5 (p <0.001). In conclusion, LV systolic function is only mildly reduced in a minority of patients after ASA for symptomatic HC; other echocardiographic and functional measures were significantly improved. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029149
Volume :
113
Issue :
8
Database :
Academic Search Index
Journal :
American Journal of Cardiology
Publication Type :
Academic Journal
Accession number :
95301662
Full Text :
https://doi.org/10.1016/j.amjcard.2014.01.417