Enantioselective One-Pot Rhodium-Catalyzed Cycloisomerization-Wittig Sequence to Chiral Functionalized 4-Alkyl 3-Alkylidene Tetrahydrofuran(on)es.

Alkyl and (hetero)aryl alkyne allyl alcohols can readily be transformed into chiral 4-alkyl 3-alkylidene tetrahydrofurans and tetrahydrofuranones bearing α,β-unsaturated carbonyl side chains in a one-pot fashion via an enantioselective rhodium-catalyzed �cycloisomerization-Wittig olefination sequence in good yields (54-86%). [ABSTRACT FROM AUTHOR]