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Economics of the antithymocyte globulins Thymoglobulin and Atgam in the treatment of acute renal transplant rejection.
- Source :
-
PharmacoEconomics . 2000, Vol. 17 Issue 3, p287-293. 7p. - Publication Year :
- 2000
-
Abstract
- <bold>Objective: </bold>To evaluate the economic implications for transplant centres, Medicare and society of treatment of corticosteroid-resistant Banff Grades I, II and III acute kidney transplant rejection with the antithymocyte globulins Thymoglobulin or Atgam.<bold>Design and Setting: </bold>This was a cost analysis of a randomised double-blind multicentre clinical trial comparing the safety and efficacy of Thymoglobulin and Atgam that was performed at 25 centres in the US in 1994 to 1996.<bold>Patients and Participants: </bold>The study enrolled 163 patients, 82 in the Thymoglobulin arm and 81 in the Atgam arm.<bold>Methods: </bold>Estimates of the cost of care from the initiation of rejection therapy to 90 days post-therapy were derived from various publicly available sources and applied to patient-specific clinical events documented in the clinical trial. Patients received either intravenous Thymoglobulin (1.5 mg/kg/day) for an average of 10 days or intravenous Atgam (15 mg/kg/day) for an average of 9.7 days.<bold>Results: </bold>On average, Thymoglobulin provided significant cost savings compared with Atgam from the perspective of society [$US5977 (1996 values); 95% confidence interval (CI) $US3719 to $US8254], Medicare ($US4967; 95% CI $US3256 to $US6678) and the transplant centre ($US3087; 95% CI $US1512 to $US4667). The overall advantage attributable to Thymoglobulin was primarily due to savings from fewer recurrent rejection treatments and less frequent return to dialysis.<bold>Conclusions: </bold>Treatment of acute renal transplant rejection with Thymoglobulin is a cost saving strategy when compared with treatment with Atgam. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11707690
- Volume :
- 17
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- PharmacoEconomics
- Publication Type :
- Academic Journal
- Accession number :
- 9526867
- Full Text :
- https://doi.org/10.2165/00019053-200017030-00006