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The CYP2C19*1/*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers.
- Source :
-
Cardiology Research & Practice . 2013, p1-7. 7p. - Publication Year :
- 2013
-
Abstract
- Background. The CYP2C19*2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether CYP2C19*2 alleles correlate with clopidogrel responsiveness following the administration of clopidogrel in healthy Malaysian volunteers. Methods. Ninety volunteers were genotyped for CYP2C19*2 and CYP2C19*3 alleles. Forty-five of 90 volunteers were included in the clopidogrel response studies and triaged into three genotypes, namely, CYP2C19*1/*1 (n = 17) CYP2C19*1/*2 (n = 21) and CYP2C19*2/*2 (n = 17). All subjects received 300 mg of clopidogrel, and platelet reactivity was assessed after a four-hour loading utilizing the VerifyNow-P2Y12 assay. Platelet activity was reported using P2Y12 reaction units (PRUs), and nonresponder status was prespecified at PRU = 230. Results. Following clopidogrel intake, CYP2C19*2/*2 carriers had a significantly higher mean PRU compared to the CYP2C19*1/*2 and CYP2C19*1/*1 (291.0 ± 62.1 versus 232.5 ± 81.4 versus 147.4 ± 87.2 PRU, P < 0.0001) carriers. Almost half of the participants (46.7%) were found to be nonresponders (3 were CYP2C19*1/*1, 11 were CYP2C19*1/*2, and 7 were CYP2C19*2/*2). Conclusion. In healthy Malaysian volunteers, CYP2C19*2 allele was associated with a decrease in platelet responsiveness to clopidogrel. However, clopidogrel nonresponders can be found not only in the carriers of CYP2C19*2/*2, but also in the carriers of CYP2C19*1/*2 and CYP2C19*1/*1. The present paper demonstrated that genotype information does not correlate with clopidogrel response, and genotyping may represent a less robust approach compared to platelet activity testing in guiding clopidogrel therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CLOPIDOGREL
*PLATELET aggregation inhibitors
*ACADEMIC medical centers
*ANALYSIS of variance
*CHI-squared test
*GENES
*POLYMERASE chain reaction
*RESEARCH funding
*STATISTICS
*PHENOTYPES
*DATA analysis
*DATA analysis software
*ACUTE coronary syndrome
*DESCRIPTIVE statistics
*PLATELET function tests
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 20908016
- Database :
- Academic Search Index
- Journal :
- Cardiology Research & Practice
- Publication Type :
- Academic Journal
- Accession number :
- 95253292
- Full Text :
- https://doi.org/10.1155/2013/128795