Functional overlaps between XLF and the ATM-dependent DNA double strand break response.

Highlights: [•] XLF is a DNA repair protein that functions in C-NHEJ. [•] XLF has functional redundancy with multiple DSB response factors including ATM. [•] XLF and the DSB response have redundant roles in B and T cell development. [•] XLF and several DSB response factors have redundant roles in general DSB repair. [•] XLF and certain DSB response factors have redundant roles in mouse development. [Copyright &y& Elsevier]