Determination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector.

Highlights: [•] The adulteration of herbal supplements for female sexual drive increase was detected. [•] The identification of flibanserin, tadalafil by LC–ESI-MS/MS-TOF was discussed. [•] Combined LC-DAD-CAD–MS-TOF method was developed to quantify detected adulterants. [•] Determination of flibanserin and tadalafil without their standards was presented. [•] The inaccuracy of proposed indirect determination was found to be ±3%. [ABSTRACT FROM AUTHOR]