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Generation and molecular characterization of a monoclonal antibody reactive with conserved epitope in sphingomyelinases D from Loxosceles spider venoms.
- Source :
-
Vaccine . Apr2014, Vol. 32 Issue 18, p2086-2092. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] A monoclonal antibody (LiD1mAb16) against a recombinant SMase D isoform was produced. [•] LiD1mAb16 was cross-reactive with protein spots from different Loxosceles species. [•] LiD1mAb16 recognizes a linear epitope in the catalytic loop of SMases D. [•] LiD1mAb16 showed neutralizing potential. [•] This mAb is a candidate for therapeutic serum development or immunodiagnostic assays. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 32
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 95126990
- Full Text :
- https://doi.org/10.1016/j.vaccine.2014.02.012