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Fipronil-amitraz- S-methoprene-triggered pemphigus foliaceus in 21 dogs: clinical, histological and immunological characteristics.

Authors :
Bizikova, Petra
Linder, Keith E.
Olivry, Thierry
Source :
Veterinary Dermatology. Apr2014, Vol. 25 Issue 2, p103-103. 11p.
Publication Year :
2014

Abstract

Background A recently launched topical ectoparasiticide containing fipronil, amitraz and S-methoprene has been associated with the development of an acantholytic pustular dermatitis similar to that of Promeris-triggered pemphigus foliaceus ( PF). Hypothesis/Objectives Our objectives were to describe the clinical, histological and immunological features of this PF-like cutaneous adverse drug reaction. Animals Twenty-one dogs with a probable or definitive diagnosis of PF-like cutaneous adverse drug reaction were identified between May 2012 and February 2013. Material and Methods Histology, direct and indirect immunofluorescence were employed to address the study objectives. Results Most dogs were middle-aged or older (median, 9 years) and of large size (median, 23 kg). In six dogs (29%), the PF-like lesions remained confined to the site of application, while 15 dogs (71%) exhibited lesions at distant sites. One or two applications of the ectoparasiticide were sufficient to trigger PF-like lesions in seven (33%) and six (29%) dogs, respectively. Systemic signs were reported in nine dogs (43%), all with lesions extending to sites distant from application areas. Tissue-bound antikeratinocyte IgG was detected in the lesional epidermis of eight of 19 (42%) cases by direct immunofluorescence, while serum antikeratinocyte IgG was detected in 10 of 14 (71%) cases by indirect immunofluorescence. Autoantibodies were found to target canine desmocollin-1 in 11 of 14 dogs (79%), but not canine desmoglein-1, by indirect immunofluorescence on transfected cells. These immunological findings were similar in cases with localized and distant disease. Conclusions and clinical importance This new topical ectoparasiticide containing fipronil, amitraz and S-methoprene is capable of triggering the development of an acantholytic pustular dermatosis that is a clinical, histological and immunological close match for Promeris-triggered PF and naturally occurring autoimmune PF in dogs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09594493
Volume :
25
Issue :
2
Database :
Academic Search Index
Journal :
Veterinary Dermatology
Publication Type :
Academic Journal
Accession number :
95094907
Full Text :
https://doi.org/10.1111/vde.12117