Immunogenicity of different recombinant rabbit hemorrhagic disease virus-like particles carrying CD8+ T cell epitope from chicken ovalbumin (OVA).

Highlights: [•] Sequences of OVA CD8+ T epitopes were integrated into VP60 of RHDV at different locations. [•] Four recombinant baculoviruses were generated by baculovirus expression system. [•] Four recombinant proteins were expressed effectively. [•] Four recombinant proteins could self-assemble into VLPs. [•] I1 and I2 were able to elicit high levels of IFN-γ secretion in the murine model. [ABSTRACT FROM AUTHOR]