Back to Search
Start Over
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.
- Source :
-
FEBS Letters . Apr2014, Vol. 588 Issue 7, p1087-1093. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Neutralising mechanism of potent therapeutic monoclonal BoNT/A antibody is exhibited. [•] Single mutation G1292R eliminates interaction of BoNT/A with all three SV2 isoforms. [•] Proof for neuronal uptake of BoNT/A by a double receptor mechanism. [•] Inactive quintuple BoNT/A mutant represents ideal antigen for vaccination. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 588
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 95016529
- Full Text :
- https://doi.org/10.1016/j.febslet.2014.02.034