Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition.

Authors :: Winters, Michael P.
Teleha, Christopher A.
Sui, Zhihua
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2014, Vol. 55 Issue 13, p2150-2153. 4p.
Publication Year :: 2014
Abstract: Abstract: Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles. [Copyright &y& Elsevier]

Subjects :: *HETEROCYCLIC compounds synthesis
*PYRAZOLES
*INTERMOLECULAR interactions
*NITRILIMINES
*RING formation (Chemistry)
*BROMIDES
*CHEMICAL derivatives

Language :: English
ISSN :: 00404039
Volume :: 55
Issue :: 13
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 95015153
Full Text :: https://doi.org/10.1016/j.tetlet.2014.02.068

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