Association of serum N-Terminal pro BNP in the Prediction Association of Serum N-Terminal pro BNP in Prediction of Left Ventricular Ejection Fraction in Patients with Systolic Ventricular Dysfunction.

Background and purpose: Annually heart failure includes about three million emergency outpatient visits in the United States. In heart failure NT-proBNP will be released in response to increased myocardial stretch Materials and methods: This study was conducted in 80 individuals attending Fatemeh Zahra Hospital, in Sari, 2010-2011. Patients with GFR≤60, age≥75, atrial fibrillation (AF) and hypertension (BP≥160.100) were excluded. The patients were carefully examined and 60 patients with DHF were divided into three groups; Group1 LVEF≤30%, group 2 LVEF≤31-39%, group 3 LVEF≤40-49%. Twenty healthy people with normal LVEF≥50% were also studied to determine the cut point. Results: The highest level of NT-pro BNP was observed in group 1 (5370.10 ± 1781.90) and the lowest level was seen in group 4 (36.75 ± 24.32). Significant differences were found between the groups in NT-pro BNP level (P<0.001). Also, incomplete and reverse correlation was observed between LVEF values and serum level NT-pro BNP (R= -0.699). Conclusion: When LVEF reduced NT-pro BNP levels increased significantly which indicates an incomplete and reverse correlation between them. This finding allows using NT-pro BNP level for approximate estimation of ejection fraction in clinical practices. [ABSTRACT FROM AUTHOR]