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The effect of CYP3 A4*1 G allele on the pharmacokinetics of atorvastatin in Chinese han patients with coronary heart disease.
- Source :
-
Journal of Clinical Pharmacology . Apr2014, Vol. 54 Issue 4, p462-467. 6p. - Publication Year :
- 2014
-
Abstract
- The present study aimed to evaluate the impact of CYP3A4*1G allele on the pharmacokinetics of atorvastatin in the Chinese Han patients with coronary heart disease (CHD). Twenty male patients of CHD with different CYP3A4*1G genotypes were orally administered a single 20 mg dose of atorvastatin. Plasma concentrations of atorvastatin and 2-hydroxyatorvastatin were measured by high-performance liquid chromatography tandem mass spectrometry. The mean area under the plasma concentration-time curve from 0 to infinity (AUC0-∞) of atorvastatin in subjects with the CYP3A4*1G/*1G genotype were 36% or 25% lower than in those with the wild-type or the *1/*1G genotype, respectively. The time to peak plasma concentration (Tmax) and oral clearance of atorvastatin (CL/F) were significantly different between subjects with the CYP3A4*1G/*1G genotype and the wild-type. The AUC0-∞ for 2-hydroxyatorvastatin in subjects with the CYP3A4*1G/*1G genotype was 44% or 31% lower than in those with the wild-type or the *1/*1G genotype, respectively. The peak plasma concentration, Tmax and apparent clearance of 2-hydroxyatorvastatin (CL/Fm) were significantly different between subjects with the CYP3A4*1G/*1G genotype and the wild-type. This study indicates that the CYP3A4*1G allele is associated with the pharmacokinetics of atorvastatin and its metabolites in those Chinese Han patients with CHD after a single oral dose. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORONARY heart disease prevention
*ANALYSIS of variance
*BIOTRANSFORMATION (Metabolism)
*CHINESE people
*GENES
*GENETICS
*HIGH performance liquid chromatography
*OXIDOREDUCTASES
*POLYMERASE chain reaction
*RESEARCH funding
*U-statistics
*DATA analysis software
*ATORVASTATIN
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00912700
- Volume :
- 54
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 94857325
- Full Text :
- https://doi.org/10.1002/jcph.229