Evaluation of the sedative, analgesic, clinicophysiological and haematological effects of intravenous detomidine, detomidine-butorphanol, romifidine and romifidine-butorphanol in standing donkeys.

The aim of this investigation was to determine and evaluate the sedative, analgesic, clinicophysiological and haematological effects of intravenous (i.v.) injection of detomidine, detomidine-butorphanol, romifidine and romifidine-butorphanol. Six standing donkeys were used. Each donkey received 4 i.v. treatments and the order of treatment was randomised with a one-week interval between each treatment. We found that i.v. injection of a combination of detomidine-butorphanol or romifidine-butorphanol produced potent neuroleptanalgesic effects thus providing better, safe and effective sedation with complete analgesia in standing donkeys compared with injection of detomidine or romifidine alone. The changes and reduction in pulse rate were within acceptable limits. The changes in clinicophysiological, haematological and biochemical values were mild and transient in these clinically healthy donkeys. [ABSTRACT FROM AUTHOR]