Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population.

Discusses a study indicating that common mutant alleles of CYP2D6 isoform of cytochrome P450 are causing the defect of CYP2D6 enzyme activity in a Japanese population. Frequency of CYP2D6 poor metabolizers in the Japanese population; Other mutations that exist in the CYP2D6 gene in the population; Detection of CYP2D6 assays for the mutations.