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Fabrication and Physical Properties of Gelatin/Sodium Alginate/Hyaluronic Acid Composite Wound Dressing Hydrogel.
- Source :
-
Journal of Macromolecular Science: Pure & Applied Chemistry . Apr2014, Vol. 51 Issue 4, p318-325. 8p. - Publication Year :
- 2014
-
Abstract
- Gelatin (Gel), sodium alginate (SA) and hyaluronic acid (HA) based various hydrogels for biomedical applications were prepared by freezing-drying method using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) as a crosslinker. The physical properties including morphology, water vapor transmission rate and hydrophilicity were investigated. The result showed the Gel/SA/HA composite hydrogels were successfully crosslinked by the crosslinking agent. All the Gel/SA/HA composite hydrogels with different compositions had highly homogeneous and interconnected pores, and the compositions had no significant effect on the surface and cross-section morphologies of the Gel/SA/HA hydrogels. The incorporation of sodium alginate enhanced the water vapor transmission capacity of the hydrogel; however, there were no significant differences between the water vapor transmission rates of all the Gel/SA/HA hydrogels. Gelatin had a low hydrophilic behavior, while sodium alginate exhibited relatively high hydrophilic behavior. The results indicate that the Gel/SA/HA hydrogel cross-linked via EDC is a potential wound dressing material capable of the adequate provision of moist environment for comfortable wound healing. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 10601325
- Volume :
- 51
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Macromolecular Science: Pure & Applied Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 94795806
- Full Text :
- https://doi.org/10.1080/10601325.2014.882693