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Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2.
- Source :
-
Neuroscience Letters . Mar2014, Vol. 563, p112-117. 6p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Ataxin-2 is phosphorylated at multiple sites by Cdk5. [•] Cdk5-mediated phosphorylation induces the proteasomal degradation of ataxin-2. [•] Ataxin-2-41Q is also degraded after phosphorylation by Cdk5. [•] Cdk5 activity may be a therapeutic approach for SCA2. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 563
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 94794547
- Full Text :
- https://doi.org/10.1016/j.neulet.2014.01.046