Back to Search
Start Over
Synthesis and cytotoxicity assay of four ganglioside GM3 analogues.
- Source :
-
European Journal of Medicinal Chemistry . Mar2014, Vol. 75, p247-257. 11p. - Publication Year :
- 2014
-
Abstract
- Abstract: A concise and efficient synthetic route for preparation of four ganglioside GM3 analogues was described. The key step is a highly regioselective and stereoselective α-sialylation from a suitably protected glycoside acceptor with a sialyl xanthate to provide the sialo-oligosaccharide in good yield. The cytotoxic properties of the synthetic gangliosides were evaluated against normal human keratinocytes and human HCT116 and K562 cancer cells. Two of them exhibited good antiproliferative activity and displayed a better cytotoxicity against cancer cell than HaCaT normal cell. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 75
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 94791641
- Full Text :
- https://doi.org/10.1016/j.ejmech.2014.01.054