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Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2014, Vol. 24 Issue 6, p1519-1522. 4p. - Publication Year :
- 2014
-
Abstract
- Abstract: Positron emission tomography (PET) is a highly sensitive quantitative imaging technique for studying molecular pathways and interactions in vivo. This imaging technique plays a key role in drug discovery, pharmacokinetics, pharmacodynamics, and assessing in vivo distribution. In this study, we designed an ethynylbenzene-substituted glycol (ME) as a versatile probe for PET labeling of oligonucleotides through a click reaction. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 94788326
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.01.082