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An evidence on G2/M arrest, DNA damage and caspase mediated apoptotic effect of biosynthesized gold nanoparticles on human cervical carcinoma cells (HeLa).

Authors :
Jeyaraj, M.
Arun, R.
Sathishkumar, G.
MubarakAli, D.
Rajesh, M.
Sivanandhan, G.
Kapildev, G.
Manickavasagam, M.
Thajuddin, N.
Ganapathi, A.
Source :
Materials Research Bulletin. Apr2014, Vol. 52, p15-24. 10p.
Publication Year :
2014

Abstract

Highlights: [•] Gold nanoparticles (AuNPs) have been synthesized using Podophyllum hexandrum L. [•] AuNPs induces the oxidative stress to cell death in human cervical carcinoma cells. [•] It activates the caspase-cascade to cellular death. [•] It is actively blocks G2/M phase of cell cycle. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00255408
Volume :
52
Database :
Academic Search Index
Journal :
Materials Research Bulletin
Publication Type :
Academic Journal
Accession number :
94697263
Full Text :
https://doi.org/10.1016/j.materresbull.2013.12.060