Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke.

Highlights: [•] We test effects of umbilical cord blood cells in a model of neonatal brain injury. [•] A novel highly reproducible model of neonatal stroke is used. [•] CD34+ cells (hematopoietic stem cells/endothelial progenitor cells) are administered. [•] Intravenous administration of the cells 48h after the insult ameliorates the injury. [•] The cell therapy augments cerebral blood flow in the peri-infarct area. [Copyright &y& Elsevier]