A simple quantitative method analysing amikacin, gentamicin, and vancomycin levels in human newborn plasma using ion-pair liquid chromatography/tandem mass spectrometry and its applicability to a clinical study.

Authors :: Bijleveld, Yuma
de Haan, Timo
Toersche, Jan
Jorjani, Sona
van der Lee, Johanna
Groenendaal, Floris
Dijk, Peter
van Heijst, Arno
Gavilanes, Antonio W.D.
de Jonge, Rogier
Dijkman, Koen P.
van Straaten, Henrica
Rijken, Monique
Zonnenberg, Inge
Cools, Filip
Nuytemans, Debbie
Mathôt, Ron
Source :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Mar2014, Vol. 951-952, p110-118. 9p.
Publication Year :: 2014
Abstract: Highlights: [•] We present an analytical method for amikacin, gentamicin, and vancomycin in plasma. [•] Only 25μL of plasma is used with this method. [•] All preset specifications of validation parameters are met. [•] The method is applied to 3 patients included in the Pharmacool trial. [•] It will be used to describe pharmacokinetics and dynamics of hypothermic newborns. [ABSTRACT FROM AUTHOR]

Subjects :: *KANAMYCIN
*GENTAMICIN
*VANCOMYCIN
*ION pairs
*LIQUID chromatography-mass spectrometry
*PHARMACOKINETICS

Language :: English
ISSN :: 15700232
Volume :: 951-952
Database :: Academic Search Index
Journal :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Publication Type :: Academic Journal
Accession number :: 94695704
Full Text :: https://doi.org/10.1016/j.jchromb.2014.01.035

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