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Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts.
- Source :
-
Journal of Pharmaceutical & Biomedical Analysis . Apr2014, Vol. 92, p6-12. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS. [•] We compared the pharmacokinetic profiles between CR and CR–ADR. [•] ADR affected the pharmacokinetic behavior of CR. [•] The four monitored alkaloids could pass through the blood brain barrier in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07317085
- Volume :
- 92
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmaceutical & Biomedical Analysis
- Publication Type :
- Academic Journal
- Accession number :
- 94694612
- Full Text :
- https://doi.org/10.1016/j.jpba.2013.12.037