Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts.

Highlights: [•] Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS. [•] We compared the pharmacokinetic profiles between CR and CR–ADR. [•] ADR affected the pharmacokinetic behavior of CR. [•] The four monitored alkaloids could pass through the blood brain barrier in vivo. [ABSTRACT FROM AUTHOR]