Genetics and epigenetics of adrenocortical tumors.

Highlights: [•] Abnormal PKA activation is present in most of cortisol-producing tumors. [•] Abnormal membrane depolarization leading to increased cytosolic calcium levels is present in the majority of APAs. [•] Although ACCs are usually sporadic, they can be a manifestation of rare cancer syndromes. [•] Subgroups of ACCs divided according to genetic and epigenetic markers have different prognosis. [•] Molecular-targeted therapies are expected to improve clinical responses in advanced ACCs. [ABSTRACT FROM AUTHOR]