Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.

Highlights: [•] Conserved binding mechanism of p53TAD peptide among Bcl-2 family proteins. [•] Targeting of MDM2-inhibiting 12-1 peptide to anti-apoptotic Bcl-XL. [•] A structural model for the Bcl-XL/12-1 peptide complex. [•] The 12-1 and pro-apoptotic BH3 peptides share the binding site of Bcl-XL. [•] Dual-targeting mechanism of 12-1 peptide to MDM2 and Bcl-XL. [ABSTRACT FROM AUTHOR]