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Ventral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion: Effect of neuroprotective agents.

Authors :
Colombo, Laura
Parravicini, Chiara
Lecca, Davide
Dossi, Elena
Heine, Claudia
Cimino, Mauro
Wanke, Enzo
Illes, Peter
Franke, Heike
Abbracchio, Maria P.
Source :
Neurochemistry International. Jan2014, Vol. 66, p43-54. 12p.
Publication Year :
2014

Abstract

Highlights: [•] VTA/SN-PFC organotypic co-cultures show cellular-specific susceptibility to OGD. [•] Neurons are mostly affected in parallel with a marked microglial activation. [•] The P2 antagonist PPADS and valproic acid protect organotypic cultures from OGD. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*SUBSTANTIA nigra
*MESENCEPHALIC tegmentum
*PREFRONTAL cortex
*LABORATORY rodents
*DISEASE susceptibility
*OPACITY (Optics)
*BUFFER solutions

Details

Language :
English
ISSN :
01970186
Volume :
66
Database :
Academic Search Index
Journal :
Neurochemistry International
Publication Type :
Academic Journal
Accession number :
94574518
Full Text :
https://doi.org/10.1016/j.neuint.2014.01.008
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