The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway.

Highlights: [•] We used Caenorhabditis elegans to investigate how TBTCL exhibits its effect on animal germline. [•] TBTCL exposure resulted in increased sterility and embryonic lethality. [•] TBTCL exposure induced increased DSBs and checkpoint activation in germline. [•] Germ cell apoptosis and proliferation arrest were induced by TBTCL exposure. [•] Checkpoint and p53 signaling pathways were found essential in response to TBTCL. [Copyright &y& Elsevier]