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Increased food allergy and vitamin D: Randomized, double-blind, placebo-controlled trial.
- Source :
-
Pediatrics International . Feb2014, Vol. 56 Issue 1, p6-12. 7p. - Publication Year :
- 2014
-
Abstract
- Background To elucidate whether maternal vitamin D supplementation during lactation improves infantile eczema and other subsequent allergic disorders, a randomized, double-blind, placebo-controlled trial was performed. Methods Mothers ( n = 164) of infants with facial eczema at 1 month check-up were randomly assigned to receive vitamin D3 supplements ( n = 82; 800 IU/day) or placebo ( n = 82) for 6 weeks from May 2009 to January 2011. The primary outcome was infantile eczema quantified on Scoring Atopic Dermatitis ( SCORAD) index at 3 month check-up, and the secondary outcomes were atopic dermatitis, food allergy, and wheeze diagnosed by doctors up to 2 years of age. Results There was no significant difference in SCORAD at 3 month check-up between the two groups. Doctor-diagnosed food allergy was significantly more common up to age 2 years in the vitamin D group (10/39, 25.7%) than in the placebo group (3/40, 7.5%; risk ratio (RR), 3.42; 95% confidence interval [CI]: 1.02-11.77; P = 0.030). Moreover, at least one secondary outcome was also significantly more common in the vitamin D group (17/39, 43.6%) than in the placebo group (7/40, 17.5%; RR, 2.49; 95% CI: 1.16-5.34; P = 0.012). Conclusions Vitamin D supplementation may not decrease the severity of infantile eczema at 3 months of age, but may rather increase the risk of later food allergy up to 2 years of age. Because a large number of subjects was lost to follow up, further study is needed to confirm the findings. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FOOD allergy
*ALLERGIES
*BREASTFEEDING
*CONFIDENCE intervals
*DIETARY supplements
*ECZEMA
*QUESTIONNAIRES
*RESEARCH funding
*U-statistics
*VITAMIN D
*STATISTICAL power analysis
*RANDOMIZED controlled trials
*RELATIVE medical risk
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 13288067
- Volume :
- 56
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Pediatrics International
- Publication Type :
- Academic Journal
- Accession number :
- 94503720
- Full Text :
- https://doi.org/10.1111/ped.12207