Knockdown of astrocyte elevated gene-1 inhibits tumor growth and modifies microRNAs expression profiles in human colorectal cancer cells.

Highlights: [•] AEG-1 expression in CRC cell lines and down-regulation or upregulation of AEG-1 in vitro. [•] Knockdown of AEG-1 inhibits cell proliferation, colony formation and invasion. [•] Upregulation of AEG-1 enhances proliferation, invasion and colony formation. [•] Knockdown of AEG-1 accumulates G0/G1-phase cells and promotes apoptosis in CRC cells. [•] AEG-1 knockdown increases 5-FU cytotoxicity. [ABSTRACT FROM AUTHOR]