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CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells.
- Source :
-
Biochemical & Biophysical Research Communications . Feb2014, Vol. 444 Issue 2, p276-281. 6p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] CagA stimulated cell proliferation and the production of IgA1 in DAKIKI cells. [•] CagA promoted the underglycosylation of IgA1 in DAKIKI cells. [•] CagA decreased the expression of C1GALT1 and its chaperone Cosmc in DAKIKI cells. [•] Helicobacter pylori infection may participate in the pathogenesis of IgAN via CagA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 444
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 94487398
- Full Text :
- https://doi.org/10.1016/j.bbrc.2014.01.050