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Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women.
- Source :
-
European Journal of Nutrition . Mar2014, Vol. 53 Issue 2, p441-448. 8p. 3 Charts, 2 Graphs. - Publication Year :
- 2014
-
Abstract
- Purpose: This study aimed to determine whether there is a relationship between iron status and bone metabolism, and to compare the effects of the consumption, as part of the usual diet, of an iron or iron and vitamin D-fortified skimmed milk on bone remodelling in iron-deficient women. Methods: Young healthy iron-deficient or iron-sufficient women (serum ferritin ≤30 ng/mL or >30 ng/mL, respectively) were recruited. Iron-deficient women were assigned to a nutritional intervention consisting of a randomised, controlled, double-blind, parallel design trial of 16 weeks during winter. They consumed, as part of their usual diet, an iron (Fe group, n = 54) or iron and vitamin D-fortified (Fe+D group, n = 55) flavoured skimmed milk (iron, 15 mg/day; vitamin D, 5 μg/day, 200 IU). The iron-sufficient women followed their usual diet without supplementation (R group, n = 56). Dietary intake, body weight, iron biomarkers, 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), procollagen-type 1 N-terminal propeptide (P1NP), and aminoterminal telopeptide of collagen I (NTx) were determined. Results: Negative correlations were found between baseline log-ferritin and log-NTx ( p < 0.001), and between transferrin and P1NP ( p = 0.002). Serum 25OHD increased (from 62 ± 21 to 71 ± 21 nmol/L, mean ± SD, p < 0.001) while P1NP and NTx decreased in Fe+D during the assay ( p = 0.004 and p < 0.001, respectively). NTx was lower in Fe+D compared to Fe at week 8 ( p < 0.05) and was higher in Fe and Fe+D compared to R throughout the assay ( p < 0.01). PTH did not show changes. Conclusions: Iron deficiency is related with higher bone resorption in young women. Consumption of a dairy product that supplies 5 μg/day of vitamin D reduces bone turnover and increases circulating 25OHD to nearly reach an optimal vitamin D status, defined as 25OHD over 75 nmol/L. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BONE remodeling
*ENRICHED foods
*ANALYSIS of variance
*ANTHROPOMETRY
*BONE resorption
*STATISTICAL correlation
*DIET
*FERRITIN
*HEMOGLOBINS
*IRON
*IRON compounds
*LONGITUDINAL method
*MILK
*NUTRITIONAL assessment
*PEPTIDES
*REGRESSION analysis
*RESEARCH funding
*STATISTICAL sampling
*SEASONS
*STATISTICS
*VITAMIN D
*WOMEN'S health
*DATA analysis
*RANDOMIZED controlled trials
*PRE-tests & post-tests
*REPEATED measures design
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
*NUTRITIONAL status
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 53
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 94448874
- Full Text :
- https://doi.org/10.1007/s00394-013-0544-4