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Triazole-Containing Hydrogels for Time-Dependent Sustained Drug Release.
- Source :
-
Macromolecular Rapid Communications . Feb2014, Vol. 35 Issue 4, p442-446. 5p. - Publication Year :
- 2014
-
Abstract
- The purpose of this study is to develop novel triazole-containing hydrogels (TGs) as drug carrier and to investigate the sustained drug release accomplished by their time-dependent swelling behavior. The synthetic pathway of TGs includes: (1) DCC-coupling on hydroxyethyl methacrylate (HEMA) to prepare HEMA-alkyne (HA), (2) click-coupling to prepare a triazole-ring-containing monomer (TM), and (3) the synthesis of a series of TGs. The aggregation between triazole rings is found to be responsible for drug release controllability. Rhodamine 6G is studied as a model anticancer drug for release experiments. The effects of pH and temperature on the properties of sustained drug release are also studied. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10221336
- Volume :
- 35
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Macromolecular Rapid Communications
- Publication Type :
- Academic Journal
- Accession number :
- 94420651
- Full Text :
- https://doi.org/10.1002/marc.201300585