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Simultaneous quantification of idelalisib, fludarabine and lenalidomide in rat plasma by using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass spectrometry.
- Source :
-
Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences . Feb2014, Vol. 949-950, p63-69. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Highly selective method for the determination of idelalisib, fludarabine and lenalidomide in plasma. [•] This is the first LC-MS/MS-based method for simultaneous determination of idelalisib, fludarabine and lenalidomide in plasma. [•] Plasma sample clean-up involves a simple liquid–liquid extraction procedures. [•] The developed LC-MS/MS-based method was applied successfully for pharmacokinetic study. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15700232
- Volume :
- 949-950
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 94408884
- Full Text :
- https://doi.org/10.1016/j.jchromb.2014.01.001