Role of SIRT1 and AMPK in mesenchymal stem cells differentiation.

Highlights: [•] SIRT1 and AMPK might mediate calorie restriction effect on MSCs differentiation. [•] SIRT1 favors MSCs differentiation toward osteoblast instead of adipocyte lineage. [•] AMPK favors MSCs differentiation toward osteoblast instead of adipocyte lineage. [•] Mechanisms of SIRT1 and AMPK action on MSCs differentiation were reviewed. [•] Synergistic interaction of SIRT1 and AMPK in MSCs differentiation was discussed. [ABSTRACT FROM AUTHOR]