High yield synthesis of d-phenylglycine and its derivatives by nitrilase mediated dynamic kinetic resolution in aqueous-1-octanol biphasic system.

Authors :: Qiu, Jian
Su, Erzheng
Wang, Wei
Wei, Dongzhi
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Feb2014, Vol. 55 Issue 8, p1448-1451. 4p.
Publication Year :: 2014
Abstract: Abstract: A strategy of nitrilase mediated dynamic kinetic resolution toward the synthesis of d-phenylglycine was developed, using aqueous-1-octanol biphasic system. Due to the efficient suppression of the decomposition of phenylglycinonitrile, a maximum yield of 81% is obtained. This result indicates that the nitrilase mediated dynamic kinetic resolution is a promising method toward the synthesis of d-phenylglycine and its derivatives. [Copyright &y& Elsevier]

Subjects :: *PHENYLGLYCINE
*CHEMICAL derivatives
*ORGANIC synthesis
*KINETIC resolution
*OCTYL alcohol
*NITRILASES
*CHEMICAL decomposition

Language :: English
ISSN :: 00404039
Volume :: 55
Issue :: 8
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 94404431
Full Text :: https://doi.org/10.1016/j.tetlet.2014.01.044

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