TNF-a is not the cause of fatty liver disease in obese diabetic mice.

Examines the role of metaformin treatment reverses fatty liver disease (FLD) in obese, leptin-deficient (ob/ob) mice by decreasing hepatic tumor necrosis factor(TNF)-α messenger RNA expression. Comparison of hepatic lipid content in ob/ob mice with or without TNF receptors; Occurrence of FLD in ob/ob mice in the absence of TNF action and TNF-induced insulin resistance.