Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments.

Abstract: Human FASN is the key enzyme required for de novo synthesis of fatty acids. Up-regulated FASN expression has been reported in various human cancers and was thought to contribute to poor prognosis and recurrence of these cancers. Studies using model cell lines have indicated the role of FASN in both intrinsic and acquired drug and radiation resistance. Recent studies suggest that FASN may play an important role in regulating gene expression such as pro-apoptotic proteins and cellular processes such as DNA repair pathways, which in turn contribute to resistance to drug and radiation-induced apoptosis. In this review, we will highlight our recent progress in understanding the mechanism of FASN-induced resistance. [Copyright &y& Elsevier]