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Chemometric analysis of soy protein hydrolysates used in animal cell culture for IgG production – An untargeted metabolomics approach.

Authors :
Gupta, Abhishek J.
Hageman, Jos A.
Wierenga, Peter A.
Boots, Jan-Willem
Gruppen, Harry
Source :
Process Biochemistry. Feb2014, Vol. 49 Issue 2, p309-317. 9p.
Publication Year :
2014

Abstract

Highlights: [•] Using an untargeted metabolomics approach 410 compounds were detected in soy protein hydrolysates. [•] Two groups of five compounds dominated the variability in the cell culture performance. [•] The effect of key compounds on IgG production was confirmed in validation experiments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13595113
Volume :
49
Issue :
2
Database :
Academic Search Index
Journal :
Process Biochemistry
Publication Type :
Academic Journal
Accession number :
94304316
Full Text :
https://doi.org/10.1016/j.procbio.2013.10.013