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CuI/Pd0 Cooperative Dual Catalysis: Tunable Stereoselective Construction of Tetra-Substituted Alkenes.
- Source :
-
Chemistry - A European Journal . Feb2014, Vol. 20 Issue 7, p1834-1838. 5p. - Publication Year :
- 2014
-
Abstract
- This paper describes a tunable and stereoselective dual catalytic system that uses copper and palladium reagents. This cooperative silylcupration and palladium-catalyzed allylation readily affords trisubstituted alkenylsilanes. Fine-tuning the reaction conditions allows selective access to one stereoisomer over the other. This new methodology tolerates different substituents on both coupling partners with high levels of stereoselectivity. The one-pot reaction involving a CuI/Pd0 cooperative dual catalyst directly addresses the need to develop more time-efficient and less-wasteful synthetic pathways. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 20
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 94232842
- Full Text :
- https://doi.org/10.1002/chem.201304284