Development of a panel of high-throughput reporter-gene assays to detect genotoxicity and oxidative stress.

Authors :: van der Linden, Sander C.
von Bergh, Anne R.M.
van Vught-Lussenburg, Barbara M.A.
Jonker, Lydia R.A.
Teunis, Marc
Krul, Cyrille A.M.
van der Burg, Bart
Source :: Mutation Research - Genetic Toxicology & Environmental Mutagenesis. Jan2014, Vol. 760, p23-32. 10p.
Publication Year :: 2014
Abstract: Highlights: [•] Assays were developed for genotoxicity, oxidative stress and cytotoxicity. [•] Assays were validated using 61 compounds. [•] The 53p CALUX is highly predictive for genotoxic activity. [•] The Nrf2 CALUX is indicative for oxidative stress. [Copyright &y& Elsevier]

Subjects :: *HIGH throughput screening (Drug development)
*BIOLOGICAL assay
*GENETIC toxicology
*OXIDATIVE stress
*CELL-mediated cytotoxicity
*ANTIOXIDANTS

Language :: English
ISSN :: 13835718
Volume :: 760
Database :: Academic Search Index
Journal :: Mutation Research - Genetic Toxicology & Environmental Mutagenesis
Publication Type :: Academic Journal
Accession number :: 94157201
Full Text :: https://doi.org/10.1016/j.mrgentox.2013.09.009

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