Design optimization study of the extraction of olive leaves performed with pressurized liquid extraction using response surface methodology.

Highlights: [•] Olive leaves were extracted by environmentally friendly technology. [•] A screening design was performed to determine significant extraction parameters. [•] Extraction yield, oleuropein content and antioxidant activity were evaluated. [•] Response surfaces investigated the impact of various experimental conditions. [•] Validation of the model confirmed the prediction capacity. [ABSTRACT FROM AUTHOR]