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Treatment effects in a transgenic mouse model of Alzheimer’s disease: A magnetic resonance spectroscopy study after passive immunization.

Authors :
Marjańska, M.
Weigand, S.D.
Preboske, G.
Wengenack, T.M.
Chamberlain, R.
Curran, G.L.
Poduslo, J.F.
Garwood, M.
Kobayashi, D.
Lin, J.C.
Jack, C.R.
Source :
Neuroscience. Feb2014, Vol. 259, p94-100. 7p.
Publication Year :
2014

Abstract

Highlights: [•] Evaluation of MRS as an outcome measure for detecting disease modification. [•] Passive immunization in transgenic mouse model of Alzheimer’s disease. [•] Treatment effect detected by MRS with myo-inositol reduction. [•] MRS shown to be a valid in vivo measure of anti-Aβ therapeutic efficacy. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*TRANSGENIC mice
*ALZHEIMER'S disease treatment
*NUCLEAR magnetic resonance spectroscopy
*IMMUNIZATION
*HEALTH outcome assessment
*DRUG efficacy
*DRUG therapy

Details

Language :
English
ISSN :
03064522
Volume :
259
Database :
Academic Search Index
Journal :
Neuroscience
Publication Type :
Academic Journal
Accession number :
94052075
Full Text :
https://doi.org/10.1016/j.neuroscience.2013.11.052
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