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DNA recognition by alternate strand triple helix formation: Affinities of oligonucleotides for...

Authors :
Olivas, Wendy M.
Maher III, L. James
Source :
Biochemistry. 2/1/94, Vol. 33 Issue 4, p983. 9p. 4 Black and White Photographs, 2 Charts, 1 Graph.
Publication Year :
1994

Abstract

Suggests that the design of high-affinity oligonucleotide probes for alternate strand recognition of natural DNA sequences may be more complex and difficult to achieve than for artificial sequences that were optimized for triple helix formation. Electrophoretic mobility shift titrations; Dimethyl sulfate footprinting; Model studies.

Details

Language :
English
ISSN :
00062960
Volume :
33
Issue :
4
Database :
Academic Search Index
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
9404191800
Full Text :
https://doi.org/10.1021/bi00170a017