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Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove ...

Authors :
Mrksich, Milan
Dervan, Peter B.
Source :
Journal of the American Chemical Society. 4/7/93, Vol. 115 Issue 7, p2572. 5p. 15 Diagrams.
Publication Year :
1993

Abstract

Discusses the distamycin A and 1-methylimidazole-2-carboxamine-netropsin peptides' simultaneous biding of the five-base-pair sequence 5'-TGTTA-3'. Importance of both molecules for binding the five-base-pair sequence; Binding of peptides as a side-by-side antiparallel heterodimer in the minor groove of double-helical DNA.

Subjects

Subjects :
*DNA
*BIOPHYSICS

Details

Language :
English
ISSN :
00027863
Volume :
115
Issue :
7
Database :
Academic Search Index
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
9401101816
Full Text :
https://doi.org/10.1021/ja00060a004