Germline mutation and protein expression analysis of mismatch repair genes MSH6 and PMS2 in Malaysian Lynch syndrome patients.

The article discusses a study which examines the spectrum of germline mutation and protein expression of DNA mismatch repair (MMR) genes MSH6 and PMS2 in Malaysian patients with Lynch syndrome. Results revealed that five Lynch syndrome patients were found to harbor germline mutations with a frequency of 8.0 % for PMS2 and 10.0 % for MSH6. It indicated that the mutation frequency of both genes was higher in Malaysian Lynch syndrome patients compared to mutation frequencies in other populations.