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Mechanism of allergic contact dermatitis from propacetamol: sensitization to activated N,N-diethylglycine.
- Source :
-
Contact Dermatitis (01051873) . Apr98, Vol. 38 Issue 4, p185. 4p. - Publication Year :
- 1998
-
Abstract
- In order to confirm the mechanism of skin sensitization to propacetamol, a pro-drug of acetaminophen, 3 patients with allergic contact dermatitis from propacetamol were patch tested with N,Ndiethylglycine phenyl ester, an activated form of N,N-diethylglycine. Positive patch tests were observed in all the patients at 10% in pet., while 20 control patients remained negative. This strongly suggests that propacetamol is acting as an activated form of N,N-diethylglycine, transferring this part of the molecule to nucleophilic residues of proteins. This also explains why reactions to acetaminophen have never been observed in patients sensitized to propacetamol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CONTACT dermatitis
*ACETAMINOPHEN
*DRUG eruptions
Subjects
Details
- Language :
- English
- ISSN :
- 01051873
- Volume :
- 38
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Contact Dermatitis (01051873)
- Publication Type :
- Academic Journal
- Accession number :
- 9383880
- Full Text :
- https://doi.org/10.1111/j.1600-0536.1998.tb05704.x