Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.

The article focuses on the study regarding the histopathological characteristics of three cases of myeloid/lymphoid or mixed lineage leukaemia (MLL) family genes MLL2 and MLL3 gene mutations. The first patient is a five-year old boy experiencing profound frontal headache associated with nausea and vomiting while the second patient is experiencing decreased appetite and headache. The study shows that MLL2/3 mutations add one more genetic variable for medulloblastoma subclassification.