Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases.

The article focuses on the role played by cyclic nucleotide phosphodiesterases in cyclic adenosine monophosphate (cAMP) compartments. cAMP diffusion is adversely affected by degradation by several phosphodiesterase isoenzymes expressed in a cell. This degradation is rarely saturated under unstimulated conditions or during neurotransmitter activation.